Samaná Bay is a bay in the eastern Dominican Republic. The Yuna River flows into the Samaná Bay, and it is located south of the town and peninsula of Samaná.
Among its features are protected islands that serve as nesting sites for pelicans and frigate birds, caves with pre-Columbian pictographs and petroglyphs, and mangrove-lined river tributaries. In the winter, many whales calve in the bay.
Adjoining the bay is Los Haitises National Park, which is popular with national and international ecotourist visitors.